The Art of Fighting Anthology invites gamers to karate kick their way through Art of Fighting, Art of Fighting 2, and The Path of the Warrior: Art of Fighting 3. Players may select from 33 classic fighters including Ryo, Robert, Mr. Big, Karate, and Lee Pai Long. Single players follow a heroic storyline through a series of one-on-one battles. Two players can fight head-to-head against one another.
Each character in the game has a unique selection of special attacks to use on enemies, and each may call on a "Desperation" attack when seconds away from defeat. The games follow events surrounding the students of the Kyokugenryu Karate Dojo. While the first two games in the series take place in Southtown, the third is set somewhere in Mexico.