Gamers take control of Dalton Brooks, a former Raven operative who wields a magnetic shield that deflects and returns projectiles, Isabelle Sinclair, an intelligence specialist who can also offer medical support, Jacob Kimble, who specializes in ranged attacks, and Naya Devereux, an assassin who is especially deadly in close quarters. The enemy AI is powerful and advanced, so making use of cover, combining attacks, and upgrading weapons are all extremely important.
Fuse can be played alone, with gamers using the LEAP feature to instantly jump back and forth between each character, but the action was designed with online multiplayer co-op in mind. Multiplayer fans can also take on waves of foes in the co-op Echelon mode, all while attempting to complete random objectives that mostly encourage aggression over defense.